Abstract Title:

Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.

Abstract Source:

Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9. PMID: 18317550

Abstract Author(s):

Eric R Secor, William F Carson, Anurag Singh, Mellisa Pensa, Linda A Guernsey, Craig M Schramm, Roger S Thrall

Article Affiliation:

Department of Immunology and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.


Bromelain, a widely used pineapple extract with cysteine protease activity, has been shown to have immunomodulatory effects in a variety of immune system models. The purpose of the present study was to determine the effects of orally administered bromelain in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD). To establish AAD, female C57BL/6J mice were sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days. Mice were gavaged with either (phosphate buffered saline)PBS or 200 mg/kg bromelain in PBS, twice daily for four consecutive days, beginning 1 day prior to OVA aerosol challenge. Airway reactivity and methacholine sensitivity, bronchoalveolar lavage (BAL) cellular differential, Th2 cytokines IL-5 and IL-13, and lung histology were compared between treatment groups. Oral bromelain-treatment of AAD mice demonstrated therapeutic efficacy as evidenced by decreased methacholine sensitivity (P

Study Type : Animal Study
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