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Article Publish Status: FREE
Abstract Title:

Boswellia resin extract and propolis derived polyphenols in patients with type III chronic prostatitis/chronic pelvic pain syndrome: An Italian prospective multicenter study.

Abstract Source:

Asian J Urol. 2022 Apr ;9(2):139-145. Epub 2021 Sep 11. PMID: 35509480

Abstract Author(s):

Fabrizio Presicce, Francesco Barrese, Andrea Cantiani, Alessio Filianoti, Domenico Tuzzolo, Paolo Di Palma, Stefano Lauretti, Stefano Brunori, Marco Martini

Article Affiliation:

Fabrizio Presicce

Abstract:

Objective: To assess the efficacy and safety of a treatment regimen based on rectal administration of Boswellia resin extract and propolis derived polyphenols in patients with type IIIa and type IIIb chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS).

Methods: Patients with type IIIa and type IIIb CP/CPPS received one rectal suppository a day for 15 days per month for 3 consecutive months. Participants were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Scores (IPSS), International Index of Erectile Function (IIEF), four-glass test, uroflowmetry, and prostate-specific antigen assessments at baseline and at Week 4, and Week 12. Primary endpoints were improvement in pain domain of NIH-CPSI and improvement of NIH-CPSI total score. Secondary outcomes included improvement of micturition and quality of life (QoL) domains of NIH-CPSI questionnaire.

Results: A total of 61 males were enrolled. No adverse events were reported. Significant improvements from baseline to Day 30 were reported for NIH-CPSI total score (mean difference: -9.2;<0.01), NIH-CPSI pain domain (mean difference: -5.5;<0.01), NIH-CPSI micturition domain, NIH-CPSI QoL domain, and IPSS total score (mean difference: -5.6;<0.01). No significant changes from baseline in terms of IIEF score or maximum flow rate were observed. At final follow-up (Day 90), further significant improvements in terms of NIH-CPSI total score (mean difference: -12.2;<0.01), NIH-CPSI pain domain (mean difference: -6.6;<0.01), NIH-CPSI micturition domain, NIH-CPSI QoL domain, and IPSS total score were reported.

Conclusion: Rectal administration of Boswellia resin extract and propolis derived polyphenols is well tolerated and delivers a significant symptomatic improvement in most patients with type IIIa and type IIIb CP/CPPS.

Study Type : Human Study

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