n/a
Abstract Title:

Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats.

Abstract Source:

Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895

Abstract Author(s):

Tarek K Motawi, Samia A Ahmed, Noha A El-Boghdady, Nadia S Metwally, Noha N Nasr

Article Affiliation:

Tarek K Motawi

Abstract:

Paracetamol (PAR) and diclofenac (DF) are the most popular consumed analgesics and anti-inflammatory medications.This study aimed to explore the protective effect of betanin (Bet) against PAR or DF induced hepato-renal damage in rats.Rats were randomly divided into five groups: Normal control (NC) group rats were given saline only. PAR group rats received PAR (400 mg/kg). PAR/Bet treated group rats administered PAR (400 mg/kg) plus Bet (25mg/kg). DF group rats received DF (10mg/kg). DF/Bet treated group rats administered DF (10mg/kg) plus Bet (25mg/kg). All drugs were given by gavage for 28 consecutive days.PAR and DF administration in high dose and long-time induced liver and kidney injury, disrupted serum lipid profile, enhanced serum levels of inflammatory and oxidative stress markers, triggered DNA fragmentation and caused drastic changes in the histopathological pictures of the two organs. Bet supplementation succeeded to ameliorate most of the biochemical changes and protected DNA from damage as obtained from comet assay. Histological features in H&E taken to different groups also mirrors this findings.Bet exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by PAR or DF overconsumption.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.