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Abstract Title:

Bergamot leaf extract treats cardiorenal metabolic syndrome and associated pathophysiological factors in rats fed with a high sugar fat diet.

Abstract Source:

Mol Cell Endocrinol. 2022 Oct 1 ;556:111721. Epub 2022 Jul 30. PMID: 35917880

Abstract Author(s):

Juliana Silva Siqueira, Taynara Aparecida Vieira, Erika Tiemi Nakandakare-Maia, Thiago Luiz Novaga Palacio, Felipe Sarzi, Jessica Leite Garcia, Bruno Henrique de Paula, Silmeia Garcia Zanati Bazan, Giovanna Baron, Luigi Tucci, Elzbieta Janda, Alessandra Altomare, Francesca Gado, Artur Junio Togneri Ferron, Giancarlo Aldini, Fabiane Valentini Francisqueti-Ferron, Camila Renata Correa

Article Affiliation:

Juliana Silva Siqueira

Abstract:

Bergamot citrus (Citrus bergamia Risso et Poiteau), have been used as a strategy to prevent or treat comorbidities associated with metabolic syndrome parameters, such as cardiorenal metabolic syndrome (CRMS). The aim was to test the effect of bergamot leaf extract on CRMS and associated pathophysiological factors in rats fed with a high sugar-fat diet. Animals were divided into two experimental groups with control diet (Control, n = 30) and high sugar-fat diet (HSF, n = 30) for 20 weeks. Once CRMS was detected, animals were redivided to begin the treatment with Bergamot Leaf Extract (BLE) by gavage (50 mg/kg) for 10 weeks: control diet + placebo (Control, n = 09), control diet + BLE (Control + BLE, n = 09), HSF diet + placebo (HSF, n = 09), HSF + BLE (n = 09). Evaluation included nutritional, metabolic and hormonal analysis; and renal and cardiac parameters. HSF groups presented obesity, dyslipidemia, hypertension, hyperglycemia, hyperinsulinemia, insulin resistance. BLE showed protection againsteffects on hypertriglyceridemia, insulin resistance, renal damage, and structural and functional alterations of the heart. Conclusion: Bergamot leaf extract shows potential as a therapeutic to treat CRMS in animals fed with a high sugar-fat diet.

Study Type : Animal Study

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