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Abstract Title:

Berberine: is a Promising Agent for Mental Disorders Treatment?

Abstract Source:

Curr Mol Pharmacol. 2022 May 9. Epub 2022 May 9. PMID: 35538795

Abstract Author(s):

Mehran Shayganfard

Article Affiliation:

Mehran Shayganfard

Abstract:

Effective and better-tolerated agents for treatment of most of psychiatric disorders are one of the main challenges. Recently, anti-inflammatory, antioxidants and neuroprotective agents as adjuvant therapy have been shown to be able to take role against the degenerative mechanisms commonly related to psychiatric conditions. Berberine, a biological active alkaloid derived from various plants, represents many pharmacological impacts, such as antimicrobial, antidiabetic, anticancer, antioxidant and anti-inflammatory activities. This compound also protects neurons and improves the survival, growth and action of nerve cells due to its high potential for crossing the blood-brain barrier. Ample evidence reported that berberine has been associated with CNS-related disorders including Alzheimer's, cerebral ischemia, mental depression, schizophrenia and anxiety. Thus, in this review we aimed to indicate the effectiveness of berberine on mental disorders.

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