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Article Publish Status: FREE
Abstract Title:

TopicalEffects on Cutaneous Wound Healing: A Study on TGF-β Expression and Clinical Outcomes.

Abstract Source:

World J Plast Surg. 2022 Mar ;11(1):86-96. PMID: 35592219

Abstract Author(s):

Mohammad Hosein Amirzade-Iranaq, Maryam Tajik, Alireza Takzaree, Mina Amirmohammadi, Farzane Rezaei Yazdi, Nasrin Takzaree

Article Affiliation:

Mohammad Hosein Amirzade-Iranaq

Abstract:

BACKGROUND: Wound healing is a critical clinical concept. We aimed to evaluate the effects of topicalessence on cutaneous wound healing.

METHODS: This randomized controlled trial was conducted in Tehran University of Medical Sciences, Tehran, Iran in 2019. Square-shaped 1.5×1.5 cm wounds were made on the neck of 60 male Wistar rats in a sterile condition. Samples were randomly divided into a control group and three experimental groups. Group A treated withessence and Vaseline. The second group received theessence, and the third group received Vaseline. Histological specimens were obtained in 4, 7, and 14days and were explored for fibroblasts, epithelial cells, inflammatory cells, and vessels. RT-PCR was performed for molecular and gene expression evaluation of TGF-β.

RESULTS: Theessence increases TGF-β gene expression as an important factor in wound healing. After 14 d, group A, who receivedand Vaseline, had 99.73% of wound healing with the mean wound size of 0.006 cmwhile wound healing in the control group was only 52%. Samples treated withhave 74.58% wound healing following by group treated with Vaseline, which was 67.02% (<0.05), respectively.

CONCLUSION: The application of theessence for wound healing accelerates the process and improves outcomes.

Study Type : Animal Study

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