Anticancer and antioxidant activities in Ganoderma lucidum wild mushrooms in Poland. - GreenMedInfo Summary
Anticancer and Antioxidant Activities inWild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.
Int J Mol Sci. 2022 Aug 19 ;23(16). Epub 2022 Aug 19. PMID: 36012645
Joanna Kolniak-Ostek
The goal of this study was to the assess anti-cancer and antioxidant properties of thefruiting body, and to identify bioactive compounds found in their extracts. Significant antiproliferative activity was observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, and NHDF cell lines. With ICvalues of 25.38µg/mL and 47.90 µg/mL, respectively, the extract was most effective against MDA-MB 231 and SW 620 cell lines. The bioactive compounds were identified using an ACQUITY UPLC-PDA-MS system. The extracts contained 13 triterpenoids and 28 polyphenols from the flavonols, phenolic acids, flavones, flavan-3-ols, and stilbenes families. Ganoderic acid derivative was found to be the most abundant triterpenoid (162.4 mg/g DW), followed by ganoderic acid B (145.6 mg/g DW). Resveratrol was the most abundant phenolic in the extract (5155.7 mg/100 g DM). The findings could explain whyextracts are used in folk medicine.