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Article Publish Status: FREE
Abstract Title:

Antibacterial Activity ofFlueck. Oleoresin Extract againstPeriodontal Pathogen.

Abstract Source:

Antibiotics (Basel). 2021 Jul 15 ;10(7). Epub 2021 Jul 15. PMID: 34356781

Abstract Author(s):

Nashwah G M Attallah, Walaa A Negm, Engy Elekhnawy, Najla Altwaijry, Elshaymaa I Elmongy, Thanaa A El-Masry, Eman A Alturki, Doaa A Yousef, Malak Y Shoukheba

Article Affiliation:

Nashwah G M Attallah

Abstract:

Flueck. oleoresin extract (frankincense) has traditionally been used in the treatment of different diseases, but there are no sufficient studies on its potential activity against periodontal pathogens. Therefore, antibacterial and antibiofilm activity of frankincense extract againstclinical isolates were studied. The phytochemical composition of the volatile components of the extract was identified by GC-MS analysis revealing 49 compounds as-nerolidyl formate, cycloartenol acetate, ursenoic acid 3-oxomethyl ester, bisabolene epoxide, and kaur-16-ene. It decreased the growth and increased the leakage of nucleotides in 58.3% and 33.3% of isolates, respectively. Additionally, it reduced the extracellular polysaccharide production and the cell surface hydrophobicity in 41.67% and 50% of the isolates, respectively. Crystal violet assay revealed inhibition of biofilm formation by the tested isolates. Light microscope and scanning electron microscope were used to examine the biofilms and they confirmed the reduction of biofilm formation by frankincense extract. Downregulation of the genes linked to biofilm formation (A,A, andB) was observed using qRT-PCR after treatment with the frankincense extract. This study suggested that the frankincense extract could exhibit antibacterial and antibiofilm activity againstisolates. Thus, the frankincense extract could be used as a treatment approach for periodontitis.

Study Type : In Vitro Study

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