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Article Publish Status: FREE
Abstract Title:

Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-decenoic Acid against.

Abstract Source:

Molecules. 2022 Feb 22 ;27(5). Epub 2022 Feb 22. PMID: 35268586

Abstract Author(s):

Kuankuan Gao, Bei Su, Jing Dai, Piwu Li, Ruiming Wang, Xiaohui Yang

Article Affiliation:

Kuankuan Gao

Abstract:

Persistent infections caused bybiofilms pose a major threat to global public health. 10-Hydroxy-2-decenoic acid (10-HDA), a main fatty acid in royal jelly, has been shown to possess various biological activities. The purpose of this study was to explore the effects of 10-HDA on the biofilms and virulence ofand its potential molecular mechanism. Quantitative crystal violet staining indicated that 10-HDA significantly reduced the biofilm biomass at sub-minimum inhibitory concentration (MIC) levels (1/32MIC to 1/2MIC). Scanning electron microscope (SEM) observations demonstrated that 10-HDA inhibited the secretion of extracellular polymeric substances, decreased bacterial adhesion and aggregation, and disrupted biofilm architecture. Moreover, 10-HDA could significantly decrease the biofilm viability and effectively eradicated the mature biofilms. It was also found that the hemolytic activity ofwas significantly inhibited by 10-HDA. qRT-PCR analyses revealed that the expressions of global regulators,, andα-hemolysin genewere downregulated by 10-HDA. These results indicate that 10-HDA could be used as a potential natural antimicrobial agent to control the biofilm formation and virulence of.

Study Type : In Vitro Study

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