Article Publish Status: FREE
Abstract Title:

Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats.

Abstract Source:

Animal Model Exp Med. 2023 Apr ;6(2):168-177. PMID: 37141004

Abstract Author(s):

Oluwafikemi Temitayo Iji, Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Omolola Victoria Awoyomi, Ademola Adetokunbo Oyagbemi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju, Evaristus Nwulia

Article Affiliation:

Oluwafikemi Temitayo Iji


BACKGROUND: The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl). This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoClexposure.

METHODS: Forty-two (42) male rats were grouped as Control; (CoCl; 300 ppm); CoCl + Glycine (50 mg/kg); CoCl + Glycine (100 mg/kg); Glycine (50 mg/kg); and Glycine (100 mg/kg). The markers of hepatic and renal damage, oxidative stress, the antioxidant defense system, histopathology, and immunohistochemical localization of neutrophil gelatinase associated lipocalin (NGAL) and renal podocin were evaluated.

RESULTS: Glycine significantly reduced the markers of oxidative stress (malondialdehyde content and HOgeneration), liver function tests (ALT, AST, and ALP), markers of renal function (creatinine and BUN), and decreased the expression of neutrophil gelatinase-associated lipocalin (NGAL) and podocin compared with rats exposed to CoCltoxicity without glycine treatment. Histopathology lesions including patchy tubular epithelial necrosis, tubular epithelial degeneration and periglomerular inflammation in renal tissues, and severe portal hepatocellular necrosis, inflammation, and duct hyperplasia were observed in hepatic tissues of rats exposed to CoCltoxicity, but were mild to absent in glycine-treated rats.

CONCLUSION: The results of this study clearly demonstrate protective effects of glycine against CoCl-induced tissue injuries and derangement of physiological activities of the hepatic and renal systems in rats. The protective effects are mediated via augmentation of total antioxidant capacity and upregulation of NGAL and podocin expression.

Print Options

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.