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Article Publish Status: FREE
Abstract Title:

Ameliorative Effects of Arctigenin on Pulmonary Fibrosis Induced by Bleomycin via the Antioxidant Activity.

Abstract Source:

Oxid Med Cell Longev. 2022 ;2022:3541731. Epub 2022 Jul 5. PMID: 35847593

Abstract Author(s):

Yueshang Wang, Xinpeng Li, Shiwen Pu, Xiao Wang, Lanping Guo, Lisheng Zhang, Zhen Wang

Article Affiliation:

Yueshang Wang

Abstract:

In this study, we evaluated the in vivo effect of arctigenin (ATG) on bleomycin-induced pulmonary fibrosis in mice and assessed the role of antioxidant activity. Hematoxylin and eosin (H&E) staining, the results of Masson's trichrome, and Sirius red staining showed that bleomycin induced obvious pathological changes and collagen deposition in the lung tissue of mice, which were effectively inhibited by ATG. Specifically, based on immunohistochemistry and western blot results, ATG inhibited the expression of fibrosis markers, such as collagen, fibronectin, and-SMA. Moreover, ATG regulated reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) in the lung tissue of pulmonary fibrosis mice and reduced the pressure of oxidative stress. ATG also regulated the TGF--induced expression of p-Akt, confirming that ATG can inhibit fibrosis through antioxidant activity modulation.

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