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Article Publish Status: FREE
Abstract Title:

Amelioration of Ovalbumin-Induced Allergic Asthma byvia Downregulation of Inflammatory Cytokines and Upregulation of Aquaporin-1 and Aquaporin-5 in Mice.

Abstract Source:

J Trop Med. 2022 ;2022:6530095. Epub 2022 Mar 30. PMID: 35401757

Abstract Author(s):

Mariam Sharif, Irfan Anjum, Arham Shabbir, Shahzada Khurram Syed, Iqra Mobeen, Muhammad Hassaan Shahid, Kamran Sarwar

Article Affiliation:

Mariam Sharif

Abstract:

() has been used traditionally to treat cough and asthma. The present study evaluates the immunomodulatory and anti-inflammatory potential ofagainst ovalbumin (OVA)-induced allergic asthma. Intraperitoneal sensitization proceeded by intranasal challenge with OVA was used to induce allergic asthma. BALB/c mice were treated with methanol, n-hexane, and ethyl acetate extracts ofand methylprednisolone one week after 2sensitization with OVA and continued for 7 days. mRNA expression levels of IL-4, IL-5, IL-13, AQP-1, AQP-5 TNF-, TGF-, and NF-kB were determined using reverse transcription polymerase chain reaction. Hematoxylin and eosin, and periodic acidic-Schiff stains were used for histopathological studies of lung tissues. The data presented all three extracts ofsignificantly ameliorated airway inflammation by reducing expression levels of IL-4, IL-5, and IL-13 and TNF-in OVA-treated mice. The suppression of goblet cells hyperplasia and inflammatory cells infiltration byinvolved low TGF-and NF-kB levels. Pretreatment withalso increased the AQP-1 and AQP-5 expression levels in mice treated with OVA. This study supported the traditional use ofand proposed thatameliorated allergic asthma by suppression of proinflammatory cytokines and elevation of AQP-1 and AQP-5 expression levels.

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