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Abstract Title:

Agaricus bisporusβ-(1 → 6)-d-glucan induces M1 phenotype on macrophages and increases sensitivity to doxorubicin of triple negative breast cancer cells.

Abstract Source:

Carbohydr Polym. 2022 Feb 15 ;278:118917. Epub 2021 Nov 20. PMID: 34973736

Abstract Author(s):

Renata Rutckeviski, Claudia Rita Corso, Yony Román-Ochoa, Thales Ricardo Cipriani, Ariana Centa, Fhernanda Ribeiro Smiderle

Article Affiliation:

Renata Rutckeviski

Abstract:

Mushroomβ-d-glucans have demonstrated immunomodulatory activity, which is initiated by their recognition by specific receptors on immune system cells surfaces. Studies indicated that β-d-glucans may present a synergistic effect with chemotherapy drugs. In this study, a linear β-(1 → 6)-d-glucan (B16), isolated from A. bisporus and previously characterized (M: 8.26 × 10 g/mol), was evaluated about its capacity to modulate THP-1 macrophages towards an M1 phenotype and induce an antitumoral activity. This was evidenced by the production of pro-inflammatory markers upon B16 treatment (30; 100 μg/mL). The breast tumor cells (MDA-MB-231) viability was not affected by treatment with B16, however, their viability markedly decreased upon treatment with the drug doxorubicin. The results showed a synergic effect of B16 and doxorubicin, which reduced the viability of MDA-MB-231 cells by 31%. Furthermore, B16 treatment provided a sustainable M1 state environment andcontributed to increase the sensitivity of breast cancer cells to the doxorubicin treatment.

Study Type : In Vitro Study

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