Acetylated polysaccharides from Pleurotus geesteranus alleviate lung injury via regulating NF-κB signal pathway. - GreenMedInfo Summary
Acetylated Polysaccharides FromAlleviate Lung Injury Via Regulating NF-κB Signal Pathway.
Int J Mol Sci. 2020 Apr 17 ;21(8). Epub 2020 Apr 17. PMID: 32316588
Xinling Song
The present work investigated the anti-inflammatory, antioxidant, and lung protection effects of acetylatedpolysaccharides (AcPPS) on acute lung injury (ALI) mice. The acetylation of AcPPS was successfully shown by the peaks of 1737 cmand 1249 cmby FTIR. The animal experiments demonstrated that lung damage can be induced by zymosan. However, the supplementation of AcPPS had potential effects on reducing lung index, remitting inflammatory symptoms (TNF-α, IL-1β, and IL-6), inhibiting NF-κB signal pathway based on up-regulating the level of IκBα and down-regulating p-IκBα level by Western blotting and immunofluorescence assay, preventing oxidative stress (ROS, SOD, GSH-Px, CAT, T-AOC, and MDA), reducing lipid accumulation (TC, TG, LDL-C, HDL-C, and VLDL-C), and alleviating lung functions by histopathologic observation. These results demonstrated that AcPPS might be suitable for natural food for prevention or remission in ALI.