Tocotrienol: Delta

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30 Diseases Researched for Tocotrienol: Delta
NameACCKFocus
Pancreatic Cancer515Locked
Ovarian Cancer110Locked
Pancreatic Neoplasms110Locked
Melanoma37Locked
Obesity23Locked
Arthritis12Locked
Breast Cancer22Locked
C-Reactive Protein12Locked
Cancers: All22Locked
Chemotherapy and Radiation Toxicity12Locked
Colorectal Cancer12Locked
Inflammation12Locked
Kidney Damage: Chemically-Induced12Locked
Metabolic Syndrome X12Locked
Parkinson's Disease12Locked
Prostate Cancer22Locked
Rheumatoid Arthritis12Locked
Bladder Cancer11Locked
Breast Cancer: Triple Negative 11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Chemotherapy Induced Myelotoxicity 11Locked
Chemotherapy-Induced Toxicity: Cisplatin11Locked
High Cholesterol11Locked
High Cholesterol: very low density lipoprotein (VLDL)11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Non-Small-Cell Lung Carcinoma11Locked
Oxidative Stress11Locked
Radiation Induced Illness: Bone Marrow11Locked
Triglycerides: Elevated11Locked
26 Pharmacological Actions Researched for Tocotrienol: Delta
NameACCKFocus
Apoptotic1024Locked
Chemopreventive518Locked
Chemotherapeutic110Locked
Antiproliferative 78Locked
Cell cycle arrest67Locked
Anti-Inflammatory Agents35Locked
NF-kappaB Inhibitor35Locked
Radioprotective35Locked
Anti-metastatic33Locked
Antioxidants23Locked
Chemosensitizer33Locked
MicroRNA modulator23Locked
Angiogenesis Inhibitors12Locked
Cardioprotective12Locked
Caspase-3 Activation12Locked
Caspase-9 Activation12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Neuroprotective Agents12Locked
P21 Activation12Locked
Renoprotective12Locked
Anti-Angiogenic11Locked
Autophagy Up-regulation11Locked
Bax/Bcl2 ratio: Increase11Locked
Nrf2 activation11Locked
Paraptosis11Locked
STAT3 Inhibitor11Locked

View the Evidence:
32 Abstracts with Tocotrienol: Delta Research

[+]

The combination of bevacizumab and tocotrienol is potent in chemotherapy refractory ovarian cancer. Feb 28, 2019

Pubmed Data : Pharmacol Res. 2019 Mar ;141:392-396. Epub 2019 Jan 9. PMID: 30639384
Article Published Date : Feb 28, 2019
Study Type : Human Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Vitamin E taken orally for 2 weeks before pancreatic surgery significantly induced apoptosis in the neoplastic cells of patients with pancreatic ductal neoplasia.Nov 30, 2015

Pubmed Data : EBioMedicine. 2015 Dec ;2(12):1987-95. Epub 2015 Nov 14. PMID: 26844278
Article Published Date : Nov 30, 2015
Study Type : Human Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Pancreatic Cancer, Pancreatic Neoplasms
Pharmacological Actions : Apoptotic, Chemopreventive
Additional Keywords : Significant Treatment Outcome
[+]

Delta tocotrienol might represent an effective option for chemopreventive strategies for melanoma.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:30502. Epub 2016 Jul 27. PMID: 27461002
Article Published Date : Dec 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Tocotrienol: Delta
Diseases : Melanoma
Pharmacological Actions : Apoptotic, Chemopreventive
[+]

A tocotrienol-rich fraction from rice bran demonstrates potent radiation protection activity.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:148791. Epub 2015 Aug 26. PMID: 26425129
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Rice Bran, Tocotrienol: Delta, Tocotrienol: Gamma
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
[+]

Chemoprevention of azoxymethane-induced colon carcinogenesis by delta-tocotrienol.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2019 06 ;12(6):357-366. Epub 2019 Apr 2. PMID: 30940630
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive
[+]

Delta-tocotrienol protects human and mouse cells from radiation damage may through suppression of IL-1β-induced NFκB/miR-30 signaling. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(3):e0122258. Epub 2015 Mar 27. PMID: 25815474
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Radioprotective
Additional Keywords : Dose Response
[+]

Dietary annatto-extracted tocotrienol reduces inflammation and oxidative stress, and improves macronutrient metabolism in obese.Apr 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Apr 13 ;13(4). Epub 2021 Apr 13. PMID: 33924335
Article Published Date : Apr 12, 2021
Study Type : Animal Study
Additional Links
Substances : Achiote, Tocotrienol: Delta
Diseases : Inflammation, Obesity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

Effects of delta-tocotrienol on ochratoxin A-induced nephrotoxicity.Oct 31, 2018

Pubmed Data : J Cell Physiol. 2018 Nov ;233(11):8731-8739. Epub 2018 May 18. PMID: 29775204
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Renoprotective
Problem Substances : Ochratoxin A
[+]

Our study represents the first comprehensive preclinical evaluation of the activity of natural vitamin E compounds in pancreatic cancer.Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cancer Ther. 2011 Dec ;10(12):2363-72. Epub 2011 Oct 4. PMID: 21971120
Article Published Date : Nov 30, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Pancreatic Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

The oral administration of delta tocotrienol may be useful in the treatment of Parkinson's disease patients.Oct 29, 2015

Pubmed Data : Neurosci Lett. 2015 Oct 30. Epub 2015 Oct 30. PMID: 26523792
Article Published Date : Oct 29, 2015
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Tamoxifen
[+]

The results of this animal study suggest that delta-tocotrienol is efficient in amelioration of collagen induced arthritis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:539540. Epub 2014 Jul 10. PMID: 25114906
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Arthritis, C-Reactive Protein, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug ;26(8):832-40. Epub 2015 Apr 14. PMID: 25979648
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation
Additional Keywords : Dose Response
[+]

δ-tocotrienol improved inflammation, heart structure and function, and liver structure and functionOct 07, 2015

Pubmed Data : Eur J Nutr. 2015 Oct 8. Epub 2015 Oct 8. PMID: 26446095
Article Published Date : Oct 07, 2015
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Tocotrienol: Gamma, Vitamin E
Diseases : Inflammation, Metabolic Syndrome X, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective
[+]

Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2020 Aug ;59(5):1975-1987. Epub 2019 Jul 6. PMID: 31280345
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Delta tocotrienol has anti-melanoma properties.Dec 01, 2010

Pubmed Data : Anticancer Res. 2010 Dec;30(12):4937-44. PMID: 21187473
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Melanoma
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Delta tocotrienol suppresses the proliferation of human pancreatic cancer cells.Jan 01, 2009

Pubmed Data : J Nutr. 2009 Jan;139(1):120-7. Epub 2008 Dec 3. PMID: 19346993
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Drug Synergy
[+]

Delta-tocotrienol acts as a chemosensitizing agent.Dec 30, 2010

Pubmed Data : Br J Pharmacol. 2010 Dec 30. Epub 2010 Dec 30. PMID: 21198544
Article Published Date : Dec 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Cancers: All, Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug Synergy
[+]

Delta-tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells.Feb 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2019 Feb 4:e12576. Epub 2019 Feb 4. PMID: 30719778
Article Published Date : Feb 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Paraptosis
[+]

Delta-tocotrienol inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis.May 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 May 9 ;8(19):31554-31567. PMID: 28404939
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive
Additional Keywords : Anti-metastatic, Antiproliferative, Cancer Stem Cells, Chemopreventive, Pancreatic Cancer, Tocotrienol: Delta, VITAMIN E
[+]

Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation.Dec 01, 2010

Pubmed Data : Haematologica. 2010 Dec;95(12):1996-2004. Epub 2010 Sep 7. PMID: 20823133
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Chemotherapy Induced Myelotoxicity , Radiation Induced Illness: Bone Marrow
Pharmacological Actions : Radioprotective
[+]

Dietary γT3-enriched food would be a simple strategy to attenuate adiposity and to lessen obesity-mediated metabolic dysfunction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 ;21(3). Epub 2016 Mar 11. PMID: 26978344
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Tocotrienol: Delta, Tocotrienols, Vitamin E: Gamma-tocotrienol
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Gamma and delta tocotrienols reduce liver triglyceride synthesis and VLDL secretion.Oct 27, 2010

Pubmed Data : J Atheroscler Thromb. 2010 Oct 27;17(10):1019-32. Epub 2010 Aug 10. PMID: 20702976
Article Published Date : Oct 27, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Tocotrienol: Gamma
Diseases : High Cholesterol: very low density lipoprotein (VLDL), Triglycerides: Elevated
[+]

Gamma- and delta-tocotrienol down-regulate cholesterol production. Sep 01, 2006

Pubmed Data : J Biol Chem. 2006 Sep 1;281(35):25054-61. Epub 2006 Jul 10. PMID: 16831864
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Tocotrienols, Vitamin E
Diseases : High Cholesterol
[+]

Here we demonstrate that α- tocopherol has little antiangiogenic effect on endothelial cells but also reduces the antiangiogenic effects of δ- Tocotrienol through modulation of its bioavailability.Mar 31, 2015

Pubmed Data : J Nutr Biochem. 2015 Apr ;26(4):345-50. Epub 2014 Dec 30. PMID: 25662730
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E, Vitamin E: alpha tocopherol
Diseases : Cancers: All
Pharmacological Actions : Anti-Angiogenic, Apoptotic, Cell cycle arrest
Additional Keywords : Bioavailability
[+]

Omega 3-DHA and delta-tocotrienol modulate lipid droplet biogenesis and lipophagy in breast cancer cells.May 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 28 ;11(6). Epub 2019 May 28. PMID: 31141912
Article Published Date : May 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Tocotrienol: Delta
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Palm tocotrienols inhibit proliferation of mouse mammary cancer cells.Dec 01, 2010

Pubmed Data : J Interferon Cytokine Res. 2010 Dec;30(12):909-16. PMID: 21121862
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Palm Oil, Tocotrienol: Alpha, Tocotrienol: Delta, Tocotrienol: Gamma, Tocotrienols
Diseases : Breast Cancer
[+]

Targeting melanoma stem cells with the Vitamin E derivative delta-tocotrienol.Jan 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 01 12 ;8(1):587. Epub 2018 Jan 12. PMID: 29330434
Article Published Date : Jan 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

The activation of miR-429 by delta-tocotrienol may be an effective approach for the prevention and treatment of triple-negative breast cancer.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(9):15648-56. Epub 2015 Sep 15. PMID: 26629059
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Chemopreventive, MicroRNA modulator
[+]

The combination of delta-tocotrienol and ferulic acid may present a new strategy for cancer prevention and therapy.Oct 23, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Oct 24 ;453(3):606-11. Epub 2014 Oct 5. PMID: 25285637
Article Published Date : Oct 23, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid, Rice Bran, Tocotrienol: Delta
Diseases : Breast Cancer, Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Natural Substance Synergy
[+]

The combined treatment of delta-tocotrienl and cisplatin significantly suppressed both NSCLC cells growth, colony formation, cell migration and invasion.Jun 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2012 Jul ;32(7):2647-55. PMID: 22753722
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Carcinoma: Non-Small-Cell Lung, Chemotherapy-Induced Toxicity: Cisplatin, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemosensitizer, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Dose Response
[+]

The data suggest that delta-tocotrienol may have potential therapeutic benefit against non-small-cell lung cancer.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2018 ;11:4301-4314. Epub 2018 Jul 24. PMID: 30100736
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

This study demonstrated for the first time that δ-T3 is a potent agent against human bladder cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0122712. Epub 2015 Apr 7. PMID: 25849286
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemosensitizer, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

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