Interleukin-18 down-regulation

Name	AC	CK
Ginsenosides	6	12
Cherry: All Varieties	1	10
Cherry: Bing	1	10
Apigenin	3	6
Astragaloside	2	4
Biochanin A	2	4
Emodin	2	4
Procyanidin B2	2	4
Thymoquinone	2	4
Ursolic Acid	2	4
Resveratrol	2	3
Arctigenin	1	2
Betulinic acid	1	2
Cabbage	1	2
Celastrol	1	2
Cyanidin 3-glucoside	1	2
Flavonoids	1	2
Galactooligosaccharides	1	2
Gastrodin	1	2
Green Tea	1	2
Gynostemma	1	2
Kaempferol	1	2
Ligustrazine	1	2
Mangiferin	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Persimmon	1	2
Polyphenols	1	2
Pomegranate	1	2
Puerarin	1	2
Quercetin	1	2
Raspberry	1	2
Sulforaphane	1	2
Theaflavins	1	2
Allicin	1	1
Alpha-Lipoic Acid	1	1
Berberine	1	1
Citrus naringin	1	1
Coriolus versicolor	1	1
Curcumin	1	1
Dogwood	1	1
Nobiletin	1	1
Olive	1	1
Oridonin	1	1
Safflower	1	1
Vitamin E: Gamma-tocotrienol	1	1

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Pubmed Data : Behav Pharmacol. 2019 12 ;30(8):700-711. PMID: 31703032

Article Published Date : Jan 11, 2019

Study Type : Animal Study

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Substances : Biochanin A

Diseases : Brain Inflammation , Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

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Pubmed Data : Nat Prod Res. 2017 Jan 20:1-4. Epub 2017 Jan 20. PMID: 28107794

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Pubmed Data : Food Nutr Res. 2021 ;65. Epub 2021 Apr 20. PMID: 33994911

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Alcoholic Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-6 Downregulation

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Electro-acupuncture alleviates chronic unpredictable stress-induced depressive- and anxiety-like behaviour and neuroinflammation.Dec 31, 2017

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Pubmed Data : ACS Omega. 2020 May 19 ;5(19):10878-10890. Epub 2020 May 5. PMID: 32455208

Article Published Date : May 18, 2020

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation

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Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

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Pubmed Data : Mol Med. 2022 01 3 ;28(1):1. Epub 2022 Jan 3. PMID: 34979900

Article Published Date : Jan 02, 2022

Study Type : Animal Study

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Diseases : Diabetes Mellitus: Type 2

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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LED therapy can attenuate neuroinflammatory responses and tissue damage following ischemic stroke.Feb 05, 2017

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Pubmed Data : J Biophotonics. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28164443

Article Published Date : Feb 05, 2017

Study Type : Animal Study

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Diseases : Stroke: Ischemic

Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

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Procyanidin B2 protects rats from paraquat-induced acute lung injury.Sep 30, 2018

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Pubmed Data : Immunobiology. 2018 Oct ;223(10):555-561. Epub 2018 Jul 6. PMID: 30025709

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID: 28189971

Article Published Date : Feb 08, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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Synergistic effect of betulinic acid, apigenin and skimmianine (BASk) in high cholesterol diet.May 31, 2021

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Pubmed Data : Cytokine. 2021 Jun ;142:155475. Epub 2021 Mar 2. PMID: 33667961

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2022 ;13:912933. Epub 2022 Jun 21. PMID: 35799788

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, ER beta receptor up-regulation, Interleukin-18 down-regulation, NF-kappaB Inhibitor

Additional Keywords : Xanthones

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Allicin alleviated acrylamide-induced NLRP3 inflammasome activation.Jan 31, 2021

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Pubmed Data : Food Chem Toxicol. 2021 Feb ;148:111937. Epub 2020 Dec 24. PMID: 33348049

Pubmed Data : Phytother Res. 2021 Oct ;35(10):5680-5693. Epub 2021 Jul 12. PMID: 34250656

Article Published Date : Sep 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Inflammation, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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View the Evidence: 94 Abstracts with Interleukin-18 down-regulation Research

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Electroacupuncture inhibits the corneal ROS/TXNIP/NLRP3 signaling pathway in a rat model of dry eye syndrome.Sep 22, 2021

Far infrared radiation therapy provides an effective treatment modality for patients with chronic lymphedema.May 31, 2017

Long-term bicycle riding improves the quality of life and reduces the severity of depression in patients suffering from chronic hemodialysis.Dec 31, 2016

Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H 22 liver tumor-bearing mice.Jul 11, 2018

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways.Jun 13, 2019

Apigenin supplement might provide a basis for developing a new dietary strategy for the prevention of chronic ulcerative colitis.Mar 31, 2016

Arctigenin may confer protection against ischemic stroke.Nov 03, 2017

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Astragaloside IV treatment ameliorated the severity of diabetic nephropathy.Dec 31, 2019

Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.Oct 31, 2020

Baicalin reduces the activity of the NLRP3 inflammasome and consequently inhibits cerebral ischemia-reperfusion injury.Sep 30, 2021

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway.Dec 31, 2018

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons.Jan 11, 2019

Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.Dec 31, 2018

Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy.Apr 25, 2021

Curcumin improves cardiac function and reduces cardiac fibrosis after myocardial infarction.Dec 31, 2020

Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.Dec 31, 2020

Electro-acupuncture alleviates chronic unpredictable stress-induced depressive- and anxiety-like behaviour and neuroinflammation.Dec 31, 2017

Electroacupuncture can alleviate the inflammatory response of synovial tissues of knee joints in knee osteoarthritis.Jun 24, 2022

Electroacupuncture can improve the neurological function and alleviate the degree of nerve injury in rats with cerebral I/R injury.Jun 24, 2022

Electroacupuncture inhibits NLRP3 activation by regulating CMPK2 after spinal cord injury.Dec 31, 2021

Electroacupuncture prevents the depression-like behavior by inhibiting the NF-κB/NLRP3 inflammatory pathway. Jan 10, 2022

Emodin alleviated pancreatic and intestinal mucosa injury in experimental severe acute pancreatitis.Aug 14, 2017

Emodin attenuates LPS-induced acute lung injury. Nov 16, 2021

Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity.Nov 30, 2019

Galactooligosaccharides protects against DSS-induced murine colitis.Jan 31, 2020

Gastrodin alleviates cerebral ischaemia/reperfusion injury.Jun 30, 2021

Gastrodin is anti-inflammatory as it effectively suppresses inflammasome in oxygen-glucose-deprivation-stimulated astrocytes.Jun 18, 2019

Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling.Jul 30, 2021

Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy.Dec 31, 2020

Ginsenoside Rg1 can inhibit inflammatory reaction, regulate lipid metabolism, and alleviate liver injury in NAFLD.May 18, 2020

Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetes. Jan 04, 2020

Ginsenosides Rb1 attenuates chronic social defeat stress-induced depressive behavior.Dec 31, 2021

Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury.Jun 11, 2019

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS‐mediated NLRP3 inflammasome activation.Dec 31, 2017

Honokiol could alleviate lipopolysaccharide-induced acute lung injury by reducing the oxidative stress and inhibiting NLRP3 inflammasome.Nov 28, 2021

Intermittent fasting attenuates inflammasome activity in ischemic stroke.Jun 30, 2014

Kaempferol might be a novel promising therapeutic agent for spinal cord injury.Apr 02, 2021

Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis.Jan 17, 2022

Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1.Jan 02, 2022

LED therapy can attenuate neuroinflammatory responses and tissue damage following ischemic stroke.Feb 05, 2017

Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects.Apr 12, 2017

MGN-3 and its hydrolysate significantly alleviated D-galactosamine induced hepatitis in rats.Dec 31, 2011

Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats.Sep 23, 2021

Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation.Dec 31, 2021

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury.Mar 17, 2022

Panax notoginseng alleviates sepsis-induced acute kidney injury.Dec 31, 2021

Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction.May 31, 2021

Pomegranate juice can be potentially used for the treatment of inflammatory bowel disease.Jun 27, 2016

Procyanidin B2 prevents lupus nephritis development in mice by inhibiting NLRP3 inflammasome activation.Jun 30, 2018

Procyanidin B2 protects rats from paraquat-induced acute lung injury.Sep 30, 2018

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy.Sep 30, 2018

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation.Mar 06, 2020

Puerarin has the capability of inhibiting vascular calcification in uremic rats by inhibiting inflammation.Jul 14, 2019

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway.Jun 09, 2021

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db miceJan 29, 2020

Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice.Nov 01, 2017

Resveratrol prevents inflammation-dependent hepatic melanoma metastasis.Jan 01, 2011

Resveratrol relieves gouty arthritis.Dec 31, 2020

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

Synergistic effect of betulinic acid, apigenin and skimmianine (BASk) in high cholesterol diet.May 31, 2021

Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response.Jul 31, 2018

The present findings indicated that ursolic acid may be a possible therapeutic agent against diabetic nephropathy.Oct 31, 2018

The study is the first to demonstrate strong effects of cyanidin-3-O-glucosideto alleviate DSS-induced colonic damage.Aug 19, 2019

Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage.Dec 31, 2017

Thymoquinone effectively modulates autophagy, pyroptosis, and pro-inflammatory, making it important in the treatment of sepsis-induced cardiac damage.Oct 19, 2018

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis May 31, 2018

Total triterpenes of Wolfiporia cocos (Schwein.) Ryvarden & Gilb exerts antidepressant-like effects.Dec 31, 2021

Ursolic acid treatment alleviates diabetic kidney injury.Dec 31, 2018

Interleukin-18 down-regulation

View the Evidence:
94 Abstracts with Interleukin-18 down-regulation Research