Abstract Title:

Therapeutic trial of hematological disorders with intermittent administration of high-dose 1-alpha-hydroxyvitamin D3.

Abstract Source:

Contrib Nephrol. 1991;91:95-101. PMID: 1800016

Abstract Author(s):

Y Imai, M Tsutsumi, T Tsunenari, M Nishikawa, T Matsui, T Natazuka, T Fujita


Aplastic anemia and myelodysplastic syndrome were successfully treated with an intermittent administration of high-dose 1 alpha-hydroxy-vitamin D3, an active analogue of 1,25-dihydroxyvitamin D3. This effect was considered to be through the differentiation-inducing and immunomodulatory actions of 1,25-dihydroxyvitamin D3. The only adverse effect was hypercalciuria which was controllable by decreasing the dose.

Study Type : Human Study

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