Abstract Title:

Vitamin B6 improves the immunogenicity of cisplatin-induced cell death.

Abstract Source:

Oncoimmunology. 2014 Oct ;3(9):e955685. Epub 2014 Dec 13. PMID: 25941619

Abstract Author(s):

Fernando Aranda, Norma Bloy, Lorenzo Galluzzi, Guido Kroemer, Laura Senovilla

Article Affiliation:

Fernando Aranda


We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

Study Type : In Vitro Study

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