Abstract Title:

Curcumin photodynamic effect in the treatment of the induced periodontitis in rats.

Abstract Source:

Lasers Med Sci. 2017 Jul 3. Epub 2017 Jul 3. PMID: 28674790

Abstract Author(s):

Letícia Helena Theodoro, Marcio Luiz Ferro-Alves, Mariéllen Longo, Marta Aparecida Alberton Nuernberg, Renata Pironato Ferreira, Adriele Andreati, Edilson Ervolino, Cristiane Duque, Valdir Gouveia Garcia

Article Affiliation:

Letícia Helena Theodoro


This study assessed the effect of curcumin as a photosensitizer in antimicrobial photodynamic therapy (aPDT) for the treatment of induced periodontitis in rats. Periodontitis was induced via a ligature around the mandibular first molar on the left side of 96 rats. The ligature was removed 7 days later, and the animals were randomized into four groups: NT, no local treatment; CUR, irrigation with curcumin solution (40 μM); LED, irradiation with a light-emitting diode (LED, InGaN, 465-485 nm, 200 mW/cm(2), 60 s); and aPDT, irrigation with curcumin solution (40 μM) followed by irradiation with LED. Eight animals from each group were euthanized at 7, 15, and 30 days post-treatment. Treatments were assessed using alveolar bone loss (ABL) in the furcation region using histological, histometric, and immunohistochemical analyses. Rats treated with aPDT exhibited less ABL at 7 days compared to the NT group, moderate pattern immunolabeling for osteoprotegerin at 30 days, and a pattern of immunolabeling for RANKL from moderate to low. Treatments resulted in smaller numbers of TRAP-positive cells compared to the NT group. aPDT as monotherapy using curcumin as a photosensitizer and LED as the light source was effective in the treatment of induced periodontitis in rats.

Study Type : Animal Study

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