Article Publish Status: FREE
Abstract Title:

Contraceptives as possible risk factors for postpartum depression: A retrospective study of the food and drug administration adverse event reporting system, 2004-2015.

Abstract Source:

Nurs Open. 2018 04 ;5(2):131-138. Epub 2018 Jan 17. PMID: 29599988

Abstract Author(s):

Megumi Horibe, Yuuki Hane, Junko Abe, Toshinobu Matsui, Yamato Kato, Natsumi Ueda, Sayaka Sasaoka, Yumi Motooka, Haruna Hatahira, Shiori Hasegawa, Yasutomi Kinosada, Hideaki Hara, Mitsuhiro Nakamura

Article Affiliation:

Megumi Horibe


Aim: Postpartum depression is a mood disorder that commonly affects women during the early postpartum period. The objective of this study was to analyse the association of postpartum depression with drugs (including contraceptive devices and implants) with spontaneously reported adverse events reported in the US Food and Drug Administration Adverse Event Reporting System database.

Design: Retrospective study.

Method: Reports of postpartum depression events between 2004-2015 were analysed with a reporting odds ratio (ROR) algorithm. The Medical Dictionary for Regulatory Activities was used to identify postpartum depression.

Results: The reporting odds ratios (95% confidence intervals, CI) of levonorgestrel (an intrauterine device with progestogen), etonogestrel (a hormonal contraceptive implant), sertraline and drospirenone (an oral contraceptive) were 12.5 (8.7-18.0), 14.0 (8.5-22.8), 12.2 (6.5-23.1) and 5.4 (2.7-10.9) respectively. Among the drugs in the US Food and Drug Administration Adverse Event Reporting System database, the use of contraceptives or an intrauterine device with progestogen might convey risk for postpartum depression.

Study Type : Human Study

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