Article Publish Status: FREE
Abstract Title:

[The effect of the essential oil from Aloysia triphylla britton (lemon verbena) on Trypanosoma cruzi in mice].

Abstract Source:

Rev Peru Med Exp Salud Publica. 2012 Mar ;29(1):61-8. PMID: 22510908

Abstract Author(s):

Juan Rojas, Olga Palacios, Sergio Ronceros

Article Affiliation:

Juan Rojas


OBJECTIVES: To determine the in-vivo anti-Trypanosoma cruzi activity of the essential oil from Aloysia triphylla in mice.

MATERIALS AND METHODS: The mice (n = 15) in the study were randomly assigned to the following groups: infected and untreated (G1), infected and treated with benznidazole 100 mg/kg (G2), infected and treated with of Aloysia triphylla essential oil 100 mg/kg (G3), infected and treated with of Aloysia triphylla essential oil 250 mg/kg (G4), uninfected and untreated (G5), and uninfected and treated with 250 mg/kg of Aloysia triphyla (G6). The infection was conducted using 104 blood T. cruzi trypomastigotes and the treatment began on the 8th day post-infection (dpi) through 28 dpi. The parasitemia was determined through optical microscopy every 2 days using 5μL of blood sampled from the tail. In dpi 14, 21 and 28, the blood sample was obtained from the queue for testing creatine kinase-MB, alanine aminotransferase and creatinine, then animals were euthanized and the heart was removed for histopathological study.

RESULTS: The essential oil of lemon verbena produced a significant reduction of the parasitemia, 85.4% with the peak at a the dose of 250 mg/ kg. It was also observed a reduction in the number of amastigotes and inflammatory infiltrates in the heart. The creatine kinase-MB plasma levels also decreased at dpi 28 as a result of such treatment.

CONCLUSIONS: Under experimental conditions, the essential oil of Aloysia triphylla (lemon verbena) has in vivo anti-Trypanosoma cruzi effect in mice.

Study Type : Animal Study

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