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Article Publish Status: FREE
Abstract Title:

Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study.

Abstract Source:

Clin Infect Dis. 2021 Jun 29. Epub 2021 Jun 29. PMID: 34185847

Abstract Author(s):

Issaka Sagara, John Woodford, Mamady Kone, Mahamadoun Hamady Assadou, Abdoulaye Katile, Oumar Attaher, Amatigue Zeguime, M'Bouye Doucoure, Emily Higbee, Jacquelyn Lane, Rathy Mohan, Justin Doritchamou, Irfan Zaidi, Dominic Esposito, Jennifer Kwan, Kaitlyn Sadtler, Alassane Dicko, Patrick E Duffy

Article Affiliation:

Issaka Sagara

Abstract:

BACKGROUND: The extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in three communities, and understand factors associated with infection.

METHODS: Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over two study visits. SARS-CoV-2 antibodies were measured using a highly specific two-antigen ELISA optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis.

RESULTS: Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged<10 years, 27.6% (737/2672) were aged 10-17 years, and 41.1% (1098/2572) were aged≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% CI: 47.5 to 69.4). This varied between sites and was 73.4% in the urban community of Sotuba, 53.2% in the rural town of Bancoumana, and 37.1% in the rural village of Donéguébougou. Study site and increased age were associated withserostatus at both study visits. There was minimal difference in reported symptoms based on serostatus.

CONCLUSION: The true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and may now approach hypothetical 'herd immunity' in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates.

Study Type : Human Study

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