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Article Publish Status: FREE
Abstract Title:

Triphala in Traditional Ayurvedic Medicine Inhibits Dengue Virus Infection in Huh7 Hepatoma Cells.

Abstract Source:

Pharmaceuticals (Basel). 2021 Nov 28 ;14(12). Epub 2021 Nov 28. PMID: 34959637

Abstract Author(s):

Aussara Panya, Kanyaluck Jantakee, Suthida Punwong, Supawadee Thongyim, Thida Kaewkod, Pa-Thai Yenchitsomanus, Yingmanee Tragoolpua, Hataichanok Pandith

Article Affiliation:

Aussara Panya

Abstract:

Traditional Triphala (three fruits), consisting ofandpresents a broad range of biological activities. However, its ability to inhibit dengue virus (DENV) infection has not been reported yet. Herein, the authors investigated the efficiency of three different Triphala formulations and its individual extract constituents to inhibit DENV infection. Treatment withextract or Triphala formulated with a high ratio ofextract showed remarkable efficiency in significantly lowering DENV infection in Vero cells. Their effects were further studied in Huh7 cells, to address its potential ability in human cells. Treatment with 100μg/mL ofextract or Triphala resulted in an approximate 3000-fold or 1000-fold lowering of virus production, respectively. Furthermore, the treatment diminishedandexpressions, which are the hallmark of the cytokine storm phenomenon in DENV infection. The HPLC profiling demonstrated gallic acid as a major compound, the treatment by which showed its ability to effectively inhibit DENV infection after virus entry. Molecular docking demonstrated that gallic acid was able to interact with DENV NS5 protein, which could be one of Triphala's antiviral mechanism. This study offers Triphala formulation and its ingredient,extract, as a natural based pharmaceutical to be used in DENV infection treatment.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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Sayer Ji
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