Article Publish Status: FREE
Abstract Title:

The Effect ofBNR17 on Postmenopausal Symptoms in Ovariectomized Rats.

Abstract Source:

J Microbiol Biotechnol. 2021 Sep 28 ;31(9):1281-1287. PMID: 34319260

Abstract Author(s):

Sol Lee, Dong Hoon Jung, Miri Park, Seung-Woo Yeon, Sang-Hyuk Jung, Sung-Il Yun, Han-Oh Park, Wonbeak Yoo

Article Affiliation:

Sol Lee


Clinical and preclinical studies have reported thatBNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions ofBNR17, we investigated the anti-menopausal effects ofBNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVX-Veh) group. Upon administration ofBNR17 after ovariectomy, calcitonin and Serotonin 2A levels increased significantly, whereas serum osteocalcin levels showed a decreasing tendency. Compared to the rats in the OVX-Veh group, those in the OVX-BNR17 group showed lower urine deoxypyridinoline levels, lower pain sensitivity, and improved vaginal cornification. Furthermore,BNR17 administration increased bone mineral density in the rats with OVX-induced femoral bone loss. These results suggest thatBNR17 administration could alleviate menopausal symptoms, indicating that this bacterium could be a good functional probiotic for managing the health of older women.

Study Type : Animal Study

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