Article Publish Status: FREE
Abstract Title:

Bactericidal Effect of the Leaf Extract fromspp. (AAB Group, Silk Subgroup), cv."Manzano"Against Multidrug-Resistant.

Abstract Source:

J Med Food. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31268391

Abstract Author(s):

Gloria María Molina-Salinas, Andrés Humberto Uc-Cachón, Luis Manuel Peña-Rodríguez, Angel de Jesús Dzul-Beh, Rosa María Escobedo Gracía-Medrano

Article Affiliation:

Gloria María Molina-Salinas


Air-dried leaves of aspp. AAB, cv."Manzano"plant, known asin the Maya culture, were sequentially extracted with hexane, ethyl acetate, and methanol; the resulting extracts were investigated for their antimycobacterial activity against susceptible and drug-resistant strains of(MTB) using the Microplate Alamar Blue Assay. Both the n-hexane extract (HE) and ethyl acetate extract (EE) showed potent activity against both strains of MTB, with the EE exhibiting the strongest activity and a Minimum Inhibitory Concentration of 12.5 and 6.25 μg/mL against susceptible and drug-resistant strains, respectively. Both extracts also demonstrated a mycobactericidal effect and a very good selectivity index when tested for cytotoxic activity on Vero monkey kidney cells, using the Sulforhodamine B assay. Our results demonstrate the efficiencyand selectivity ofspp. AAB, cv."Manzano"against MTB strains and support its traditional use as remedy against tuberculosis in Maya traditional medicine.

Study Type : In Vitro Study

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