Abstract Title:

Retz. Fruit Extracts Inhibit Bacterial Triggers of Some Autoimmune Diseases and Potentiate the Activity of Tetracycline.

Abstract Source:

Indian J Microbiol. 2018 Dec ;58(4):496-506. Epub 2018 Jul 12. PMID: 30262960

Abstract Author(s):

Aaron Mandeville, Ian Edwin Cock

Article Affiliation:

Aaron Mandeville


Retz. is a northern Indian plant species known for its anti-inflammatory and antimicrobial properties.fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantified by both liquid dilution and disc diffusion techniques. To screen for combinatorial effects, thefruit extracts were combined with a range of conventional antibiotics and tested against each bacteria using a liquid dilution assay. Where synergy was detected, the optimal ratios were determined using isobologram analysis. Toxicity was examined usingnauplii and HDF bioassays.fruit methanolic, aqueous and ethyl acetate extracts displayed strong antimicrobial activity against the bacterial triggers of all autoimmune inflammatory diseases except, for which only moderate inhibition was observed. Indeed, MIC values as low as 195 μg/mL were measured for the aqueous extract against a resistant strain of. Of further note, both the aqueous and ethyl acetate extracts interacted synergistically in combination with tetracycline against(Σ FIC 0.38 and 0.25 respectively). All extracts were nontoxic in theand HDF toxicity assays, further indicating their potential for medicinal use.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.