Article Publish Status: FREE
Abstract Title:

Tea andcomplex induces apoptosis of human liver cancer cells via PI3K/AKT/mTOR pathway.

Abstract Source:

Chin Herb Med. 2022 Jul ;14(3):449-458. Epub 2022 Jun 22. PMID: 36118010

Abstract Author(s):

Shuai Wen, Ran An, Dongli Li, Junxi Cao, Zhigang Li, Wenji Zhang, Ruohong Chen, Qiuhua Li, Xingfei Lai, Lingli Sun, Shili Sun

Article Affiliation:

Shuai Wen


Objective: In this study, black tea and(BT-CM), yellow tea and(YT-CM), green tea and(GT-CM) as subjects, the active ingredient content and antioxidant activity of three tea and(T-CM) were analyzed. The effects of three T-CMs on apoptosis of liver cellsand its mechanism were further explored.

Methods: National standard method and HPLC were used for active ingredient analysis. MTT, cell flow cytometry and Western blot were used to analyze the effects of three T-CMs on cell proliferation, apoptosis, and its underlying molecular mechanism.

Results: The content of tea polyphenols, free amino acids, ratio of polyphenols and amino acids, ester catechins, non-ester catechins and caffeine in YT-CM and GT-CM was significantly higher than that of BT-CM. Theantioxidant capacity of YT-CM and GT-CM was also significantly stronger than that of BT-CM. Three T-CMs had the effects of inhibiting proliferation, arresting cell cycle and inducing apoptosis in HepG2 and Bel7402 cells, especially YT-CM and GT-CM. Western blot analysis showed three T-CMs activated PI3K/AKT/mTOR signaling pathway and regulated the expression levels of apoptosis-related proteins Bax, Bcl-2 and Caspase-3/9. YT-CM and GT-CM had better ability to change the signal pathway than BT-CM.

Conclusion: In short, T-CMs, which combined different degrees of fermentation tea with, were rich in nutrients and biologically active substances. T-CMs, especially YT-CM and GT-CM, are healthy drinks that help to prevent and treat liver cancer.

Study Type : In Vitro Study

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Sayer Ji
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