Article Publish Status: FREE
Abstract Title:

Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.

Abstract Source:

Nutrients. 2021 Aug 24 ;13(9). Epub 2021 Aug 24. PMID: 34578794

Abstract Author(s):

Xiangyu Zhou, Qingming Cao, Caroline Orfila, Jian Zhao, Lin Zhang

Article Affiliation:

Xiangyu Zhou


CONTEXT: Astaxanthin (ASX), a xanthophyll carotenoid derived from microalgae, mitigating skin photoaging and age-related skin diseases by its antioxidant and anti-inflammatory effects in animal studies.

OBJECTIVE: The aim was to systematically evaluate if ASX applications have anti-ageing effects in humans.

METHODS: A comprehensive search of PubMed, Scopus and Web of Science found a total of eleven studies. Nine randomised, controlled human studies assessed oral ASX effects and two open-label, prospective studies evaluated topical, oral-topical ASX effects on skin ageing.was used to extract mean values and standard deviations of baseline and endpoint, and Cochrane Collaboration's tool assessed RoB for all included studies. Review Manager 5.4 was used to conduct meta-analysis of RCTs; the results were reported as effect size± 95% confidence interval.

RESULTS: Oral ASX supplementation significantly restored moisture content (SMD = 0.53; 95% CI = 0.05, 1.01; I= 52%;= 0.03) and improved elasticity (SMD = 0.77; 95% CI = 0.19, 1.35; I= 75%;= 0.009) but did not significantly decrease wrinkle depth (SMD = -0.26; 95% CI = -0.58, 0.06; I= 0%;= 0.11) compared to placebo. Open-label, prospective studies suggested slightly protective effects of topical and oral-topical ASX applications on skin ageing.

CONCLUSIONS: Ingestion and/or topical usages of ASX may be effective in reducing skin ageing and have promising cosmetical potential, as it improves moisture content and elasticity and reduces wrinkles.

Study Type : Meta Analysis, Review

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Sayer Ji
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