Abstract Title:

Vitamin C Improves Therapeutic Effects of Adipose-derived Stem Cell Transplantation in Mouse Tendonitis Model.

Abstract Source:

In Vivo. 2017 May-Jun;31(3):343-348. PMID: 28438861

Abstract Author(s):

Kyung-Ku Kang, Eun-Joo Lee, Youg-Deuk Kim, Myung-Jin Chung, Jun-Young Kim, Shin-Yoon Kim, Su-Kyeung Hwang, Kyu-Shik Jeong

Article Affiliation:

Kyung-Ku Kang


BACKGROUND/AIM: We hypothesized that combined therapy using adipose-derived stem cells (ASCs) and vitamin C might improve tendon regeneration in tendonitis. To determine combined effects of ASC transplantation with vitamin C, we used senescence marker protein 30 (SMP30)-knockout (KO) mice that cannot biosynthesize vitamin C by themselves.

MATERIALS AND METHODS: SMP30-KO were divided into four groups: Control, vitamin C, ASCs, and vitamin C plus ASCs. Tendonitis was induced in the achilles tendons via injection of collagenase type I. After 1 week, ASCs were injected into the intratendonal region. After 30 days, all mice were sacrificed and Achilles tendons were isolated.

RESULTS: Gross and microscopic findings showed mice treated with combination of ASC transplantation and vitamin C showed better tendon regeneration than those in other groups. This combination led to higher serum vitamin C levels than use of vitamin C alone. This indicates that the vitamin C-treated group used more vitamin C as a precursor to collagen synthesis, whereas vitamin C was in excess in the combination group because of the added effect of ASCs on tendon healing.

CONCLUSION: This study showed that vitamin C improved the effect of ASC transplantation on tendonitis by inducing a better stem cell niche.

Study Type : Animal Study

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Sayer Ji
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