Article Publish Status: FREE
Abstract Title:

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.

Abstract Source:

Sci Rep. 2016 Jun 27 ;6:28484. Epub 2016 Jun 27. PMID: 27346372

Abstract Author(s):

Jun Chen, Nicholas Chia, Krishna R Kalari, Janet Z Yao, Martina Novotna, M Mateo Paz Soldan, David H Luckey, Eric V Marietta, Patricio R Jeraldo, Xianfeng Chen, Brian G Weinshenker, Moses Rodriguez, Orhun H Kantarci, Heidi Nelson, Joseph A Murray, Ashutosh K Mangalam

Article Affiliation:

Jun Chen


Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patientshad distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.

Study Type : Human Study

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