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Abstract Title:

Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa.

Abstract Source:

J Nat Med. 2015 Jan ;69(1):142-7. Epub 2014 Oct 10. PMID: 25300344

Abstract Author(s):

Takahiro Matsumoto, Seikou Nakamura, Katsuyoshi Fujimoto, Tomoe Ohta, Keiko Ogawa, Masayuki Yoshikawa, Eri Onishi, Masashi Fukaya, Hisashi Matsuda

Article Affiliation:

Takahiro Matsumoto

Abstract:

The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit the release ofβ-hexosaminidase as a maker of degranulation from rat basophil leukemia (RBL-2H3) cells. Two new diarylheptanoids, diarylcomosols IV and V, were isolated from the methanolic extract. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence.The isolated diarylheptanoids showed inhibitory activity, and the structural requirements of the active constituents for the inhibition were clarified.

Study Type : In Vitro Study

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