Article Publish Status: FREE
Abstract Title:

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter.

Abstract Source:

Food Nutr Res. 2017 ;61(1):1364117. Epub 2017 Aug 23. PMID: 28970778

Abstract Author(s):

Jialin Wang, Mi Huang, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Xinzhou Yang, Ping Zhao

Article Affiliation:

Jialin Wang


The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oiland. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression.

Study Type : Animal Study

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Sayer Ji
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