Abstract Title:

Potential influence of hormones in the development of slipped capital femoral epiphysis: a preliminary study.

Abstract Source:

J Pediatr Orthop B. 2007 Jan;16(1):1-5. PMID: 17159524

Abstract Author(s):

Kyriakos A Papavasiliou, John M Kirkos, George A Kapetanos, John Pournaras

Article Affiliation:

3rd Orthopaedic Department, Aristotle University of Thessaloniki-Medical School, Papageorgiou General Hospital, Thessaloniki, Greece. kyrpap2005@yahoo.com


The potential influence of hormonal imbalance on the development of slipped capital femoral epiphysis was assessed through a prospective clinical study. The serum levels of T3, T4, thyroid-stimulating hormone, testosterone, estradiol, dehydroepiandrosterone-sulfate, follicle-stimulating hormone, luteinizing hormone, human growth hormone, adrenal cortex hormone and cortisol were evaluated in seven boys and seven girls. Forty-three out of 154 hormonal determinations (27.9%) were abnormal. The results showed increased incidence of pathological values mainly in the levels of follicle-stimulating-hormone, luteinizing-hormone and testosterone. No patient had clinical findings of endocrinopathy. A (possibly) temporary hormonal disorder may play a potentially significant role in the development of slipped capital femoral epiphysis.

Study Type : Human Study

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