Abstract Title:

Antitumor quinazoline alkaloids from the seeds of Peganum harmala.

Abstract Source:

J Asian Nat Prod Res. 2015 May ;17(5):595-600. PMID: 26166311

Abstract Author(s):

Chun-Hua Wang, Hong Zeng, Yi-Hai Wang, Chuan Li, Jun Cheng, Zhi-Jun Ye, Xiang-Jiu He

Article Affiliation:

Chun-Hua Wang


A phytochemical study on the methanol extracts from the seeds of Peganum harmala L. led to a new quizonaline alkaloid (S)-vasicinone-1-O-β-d-glucopyranoside (1) and four known ones, (R)-vasicinone-1-O-β-d-glucopyranoside (2), (S)-vasicinone (3), vasicine (4), and deoxyvasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.

Study Type : In Vitro Study

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