Abstract Title:

The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway.

Abstract Source:

Biomed Pharmacother. 2018 Apr ;100:388-393. Epub 2018 Feb 16. PMID: 29454287

Abstract Author(s):

Andressa Corneo Gazola, Geison Modesti Costa, Silvana Maria Zucolotto, Leonardo Castellanos, Freddy Alejandro Ramos, Thereza Christina Monteiro de Lima, Eloir Paulo Schenkel

Article Affiliation:

Andressa Corneo Gazola


The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2''-O-xyloside, vitexin-2''-O-glucoside, orientin-2''-O-xyloside and orientin-2''-O-glucoside. Vitexin-2"-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Sedative effects

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