Abstract Title:

Seasonal variation in the incidence rate of tuberculous meningitis is associated with sunshine hours.

Abstract Source:

Epidemiol Infect. 2013 Mar ;141(3):459-62. Epub 2012 May 31. PMID: 22647556

Abstract Author(s):

D H Visser, J F Schoeman, A M VAN Furth

Article Affiliation:

D H Visser


Tuberculous meningitis (TBM) is a severe complication of tuberculosis and occurs mainly during early childhood. The incidence rate of TBM varies with season, and serum vitamin D levels, which are dependent on sunlight, might play a role. We studied the association between TBM incidence rate and hours of sunshine in Cape Town, South Africa and found a significant association between the incidence rate of TBM and hours of sunshine 3 months earlier (incidence rate ratio per 100 sunshine hours 0·69, 95% confidence interval 0·54-0·88, P = 0·002). The association supports the hypothesis that vitamin D might play a role in the pathophysiology of TBM. Further prospective studies in which vitamin D status is measured are necessary to determine causality.

Study Type : Human Study

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