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Abstract Title:

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells.

Abstract Source:

Nat Commun. 2021 06 30 ;12(1):4043. Epub 2021 Jun 30. PMID: 34193870

Abstract Author(s):

Jae Hyung Jung, Min-Seok Rha, Moa Sa, Hee Kyoung Choi, Ji Hoon Jeon, Hyeri Seok, Dae Won Park, Su-Hyung Park, Hye Won Jeong, Won Suk Choi, Eui-Cheol Shin

Article Affiliation:

Jae Hyung Jung

Abstract:

Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex vivo assays to evaluate SARS-CoV-2-specific CD4and CD8T cell responses in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO), and find that memory T cell responses are maintained during the study period regardless of the severity of COVID-19. In particular, we observe sustained polyfunctionality and proliferation capacity of SARS-CoV-2-specific T cells. Among SARS-CoV-2-specific CD4and CD8T cells detected by activation-induced markers, the proportion of stem cell-like memory T (T) cells is increased, peaking at approximately 120 DPSO. Development of Tcells is confirmed by SARS-CoV-2-specific MHC-I multimer staining. Considering the self-renewal capacity and multipotency of Tcells, our data suggest that SARS-CoV-2-specific T cells are long-lasting after recovery from COVID-19, thus support the feasibility of effective vaccination programs as a measure for COVID-19 control.

Study Type : Human Study

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