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Article Publish Status: FREE
Abstract Title:

SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.

Abstract Source:

Clin Transl Immunology. 2021 ;10(7):e1306. Epub 2021 Jul 5. PMID: 34257967

Abstract Author(s):

John Tyler Sandberg, Renata Varnaitė, Wanda Christ, Puran Chen, Jagadeeswara R Muvva, Kimia T Maleki, Marina García, Majda Dzidic, Elin Folkesson, Magdalena Skagerberg, Gustaf Ahlén, Lars Frelin, Matti Sällberg, Lars I Eriksson, Olav Rooyackers, Anders Sönnerborg, Marcus Buggert, Niklas K Björkström, Soo Aleman, Kristoffer Strålin, Jonas Klingström, Hans-Gustaf Ljunggren, Kim Blom, Sara Gredmark-Russ,

Article Affiliation:

John Tyler Sandberg

Abstract:

Objectives: Humoral and cellular immunity to SARS-CoV-2 following COVID-19 will likely contribute to protection from reinfection or severe disease. It is therefore important to characterise the initiation and persistence of adaptive immunity to SARS-CoV-2 amidst the ongoing pandemic.

Methods: Here, we conducted a longitudinal study on hospitalised moderate and severe COVID-19 patients from the acute phase of disease into convalescence at 5 and 9 months post-symptom onset. Utilising flow cytometry, serological assays as well as B cell and T cell FluoroSpot assays, we assessed the magnitude and specificity of humoral and cellular immune responses during and after human SARS-CoV-2 infection.

Results: During acute COVID-19, we observed an increase in germinal centre activity, a substantial expansion of antibody-secreting cells and the generation of SARS-CoV-2-neutralising antibodies. Despite gradually decreasing antibody levels, we show persistent, neutralising antibody titres as well as robust specific memory B cell responses and polyfunctional T cell responses at 5 and 9 months after symptom onset in both moderate and severe COVID-19 patients.

Conclusion: Our findings describe the initiation and, importantly, persistence of cellular and humoral SARS-CoV-2-specific immunological memory in hospitalised COVID-19 patients long after recovery, likely contributing towards protection against reinfection.

Study Type : Human Study

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