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Abstract Title:

The Role of Beetroot Extract in Overcoming Chemoresistance of Neoadjuvant Adriamycin Cyclophosphamide Regimen by Targeting Immune Response in Tumor Microenvironment: A Preclinical Study in Mammary Adenocarcinoma Rats.

Abstract Source:

Asian Pac J Cancer Prev. 2022 Mar 1 ;23(3):1061-1068. Epub 2022 Mar 1. PMID: 35345381

Abstract Author(s):

Sri Susilowati, Hermawan Istiadi, Suhartono Suhartono, Yan Wisnu Prajoko, Ignatius Riwanto, Neni Susilaningsih, Catharina Suharti

Article Affiliation:

Sri Susilowati


OBJECTIVE: This study aims to determine the role of beetroot extract in overcoming the chemoresistance of Neoadjuvant Adriamycin Cyclophosphamide (NAC) regimens with a target immune response in the tumour microenvironment at the pre-clinical stage.

METHODS: This study was conducted on rats with 7,12-Dimethyl Benz (α) Anthracene (DMBA) induced mammary adenocarcinoma. Adriamycin Cyclophosphamide was given in 4 cycles, whereas beetroot extract was administered three times each cycle. Observations of CD8 T cells and Myeloid Derivative Suppressive Cells (MDSC) expression levels and pathological responses were carried out on tumour tissue taken at the end of the observation.

RESULTS: Supplementation of beetroot extract to NAC could significantly increase CD8 T cells and decrease MDSC in the tumour microenvironment. The addition of beetroot extract gave a better pathological response.

CONCLUSION: Beetroot extract enhances the immune response in the tumor microenvironment so that it has the potential to overcome chemoresistance in NAC.

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Sayer Ji
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