Article Publish Status: FREE
Abstract Title:

Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview.

Abstract Source:

Front Pharmacol. 2017 ;8:702. Epub 2017 Oct 17. PMID: 29089889

Abstract Author(s):

Lian Duan, Xingjiang Xiong, Junyuan Hu, Yongmei Liu, Jun Li, Jie Wang

Article Affiliation:

Lian Duan


Coronary artery disease (CAD) is a major public health problem and the chief cause of morbidity and mortality worldwide., a valuable herb in traditional Chinese medicine (TCM) with obvious efficacy and favorable safety, shows a great promise as a novel option for CAD and is increasingly recognized clinically. Firstly, this review introduced recent clinical trials on treatment with PNS either alone or in combination with conventional drugs as novel treatment strategies. Then we discussed the mechanisms of and saponins (PNS), which can regulate signaling pathways associated with inflammation, lipid metabolism, the coagulation system, apoptosis, angiogenesis, atherosclerosis, and myocardial ischaemia.

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