Abstract Title:

Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cells.

Abstract Source:

Toxicon. 2010 Aug 1;56(1):29-35. Epub 2010 Mar 20. PMID: 20307562

Abstract Author(s):

Naoko Morinaga, Kinnosuke Yahiro, Masatoshi Noda

Article Affiliation:

Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. nmorinaga@faculty.chiba-u.jp


Resveratrol (3,4',5-trihydroxystilbene), a natural polyphenol found in red grapes, berries and peanuts, exhibits anti-inflammatory, cell-growth modulatory, and anticarcinogenic effects. In this report, we show that resveratrol inhibited cholera toxin (CT)-induced cyclic AMP accumulation in Vero cells. Resveratrol suppressed the CT activity by suppressing the internalization of CT and traffic to the Golgi apparatus without affecting CT binding to cells. Further, resveratrol partially precipitated CT from solution, and suppressed CT ADP-ribosyltransferase activity. These data suggest that resveratrol may inhibit CT-induced activity directly by associating with CT and suppressing its enzymatic activity, and indirectly by inhibiting CT endocytosis into cells.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.