Abstract Title:

[Effect of Rehmannia glutinosa Libosch water extraction on gene expression of proinsulin in type 2 diabetes mellitus rats].

Abstract Source:

Vasc Med. 2002;7(4):265-7. PMID: 18619246

Abstract Author(s):

Qing-Yu Meng, Xiu-Fang Lv, Xiu-Dong Jin


OBJECTIVE: To investigate the mechanisms of treating 2-DM by Rehmannia glutinosa Libosch water extraction (RGLE). METHODS: The mRNA level of proinsulin in rats panreas tissue was examined by semi-quatitativa RT-PCR,and the protein was measured by SDS-PAGE. RESULTS: The mRNA and protein expressions of proinsulin in RGLE group were higher than those of diabetic model group (P<0.01). The levels of FPG decreased. FINS,IS, HbetaCI increased (P<0.01). CONCLUSION: It may be the mechanism how the RGLE to decline high FPG and cure the 2-DM.

Study Type : Animal Study

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