Article Publish Status: FREE
Abstract Title:

Red Dragon Fruit () Extract Decreases Lactic Acid Level and Creatine Kinase Activity in Rats Receiving Heavy Physical Exercise.

Abstract Source:

Open Access Maced J Med Sci. 2019 Jul 30 ;7(14):2232-2235. Epub 2019 Jul 20. PMID: 31592070

Abstract Author(s):

Novita Sari Harahap, Rina Amelia

Article Affiliation:

Novita Sari Harahap


BACKGROUND: Heavy physical exercise causes relative hypoxia. In hypoxic condition, the cell's energy comes from anaerobic metabolism that produces lactic acid. An increment of oxygen need leads to ischemia-reperfusion, triggers free radical formation and damages muscles. Creatine kinase (CK) is a marker of muscle tissue damage. Red dragon fruit (RDF) has potential as antioxidant to reduce free radical formation.

AIM: This study aims to determine RDF extract potential to reduce the lactic acid level and CK activity after heavy physical exercise.

METHODS: A total of 32 male rats (Rattus Norvegicus) were randomly divided into 4 groups: group NORDF, treated heavy physical exercise and distilled water; group RDF100, treated heavy physical exercise and at 100 mg/kg BW RDF extract; group RDF200, treated heavy physical exercise and at 200 mg/kg BW RDF extract and group RDF300, treated heavy physical exercise and at 300 mg/kg BW RDF extract. The rats swam for 20 minutes, 3 times a week for 3 weeks.

RESULTS: RDF300 group showed lower lactic acid level and CK activity as compared to that of NORDF (p = 0.00) and RDF100 (p = 0.00) groups, but RDF300 are not significantly different for lactic acid (p = 0.45) and for CK (p = 0.68).

CONCLUSION: Red dragon fruit extract has potential in lowering lactic acid level and CK activity in male rats receiving heavy physical exercise.

Study Type : Animal Study

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