Abstract Title:

Rabies encephalitis in a child: a failure of rabies post exposure prophylaxis?

Abstract Source:

BMJ Case Rep. 2015 ;2015. Epub 2015 Jan 14. PMID: 25589528

Abstract Author(s):

Faten Tinsa, Aida Borgi, Imen Jahouat, Khadija Boussetta

Article Affiliation:

Faten Tinsa


Rabies remains a serious public health problem in many developing countries. The diagnosis is easy when a non-immunised patient presents with hydrophobia and hypersalivation after a bite by a known rabid animal but more difficult when a patient presents atypical symptoms after having received rabies postexposure prophylaxis. Rabies postexposure prophylaxis failure is rare. We report a case of a 6-year-old boy who presented febrile seizure with agitation and cerebellar signs, without hydrophobia or hypersalivation, 17 days after a dog bite. Despite four doses of rabies vaccine and immunoglobulin, he died. Diagnostic confirmation of rabies encephalitis was made in post mortem on brain biopsies by fluorescent antibody technique.

Study Type : Human: Case Report
Additional Links
Anti Therapeutic Actions : Vaccination: Rabies : CK(43) : AC(15)

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