Article Publish Status: FREE
Abstract Title:

Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells.

Abstract Source:

Sci Rep. 2016 Nov 21 ;6:37417. Epub 2016 Nov 21. PMID: 27869173

Abstract Author(s):

Yuanyuan Kong, Gege Chen, Zhijian Xu, Guang Yang, Bo Li, Xiaosong Wu, Wenqin Xiao, Bingqian Xie, Liangning Hu, Xi Sun, Gaomei Chang, Minjie Gao, Lu Gao, Bojie Dai, Yi Tao, Weiliang Zhu, Jumei Shi

Article Affiliation:

Yuanyuan Kong


Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and down-regulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.

Study Type : In Vitro Study

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