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Abstract Title:

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy.

Abstract Source:

Environ Sci Pollut Res Int. 2022 Jun 30. Epub 2022 Jun 30. PMID: 35771324

Abstract Author(s):

Mohammed S Mahmoud, Attalla F El-Kott, Hussah I M AlGwaiz, Samah M Fathy

Article Affiliation:

Mohammed S Mahmoud

Abstract:

The present study aimed to assess the antioxidative, anti-inflammatory, antiapoptotic, and anti-depression impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) in the hippocampus and cerebral cortex of CCl-induced hepatic encephalopathy mouse model. High-performance liquid chromatography was used to detect marker compounds: rutin andβ-sitosterol. Animals were divided into four groups: vehicle group, CCl-treated group, MOLE-treated group, and (CCl + MOLE) group treated with MOLE for 14 days before CCl-induced neurotoxicity. MOLE decreased alanine aminotransferase, aspartate aminotransferase, corticosterone, and ammonia levels in serum and improved the antioxidant status of CCl-treated mice in the hippocampus and cerebral cortex. It reduced the expression of toll-like receptor 4 (TLR4), TLR2, myeloid differentiation primary response 88 (MYD88), and nuclear factor-kappa B (NF-κB) genes and the protein levels of the pro-inflammatory cytokines. MOLE also attenuated apoptosis, as revealed by the reduced expression of caspase3, and prevented histological deterioration. Furthermore, MOLE attenuated CCl-induced anxiety and depression-like behavioral changes. Collectively, MOLE modulates neuroinflammation, oxidative stress, TLR4/2-MyD88/NF-κB signaling, and apoptosis in the hippocampus and cerebral cortex of the hepatic encephalopathy experimental model.

Study Type : Animal Study

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