Article Publish Status: FREE
Abstract Title:

Protective Effect of Acteoside on Ovariectomy-Induced Bone Loss in Mice.

Abstract Source:

Int J Mol Sci. 2019 Jun 18 ;20(12). Epub 2019 Jun 18. PMID: 31216684

Abstract Author(s):

Lingling Yang, Bo Zhang, Jingjing Liu, Yanhong Dong, Yanting Li, Nan Li, Xiaojun Zhao, Hunter Snooks, Changling Hu, Xueqin Ma

Article Affiliation:

Lingling Yang


Acteoside, an active phenylethanoid glycoside compound isolated from herbs of, was chosen for the investigation of anti-osteoporotic effect on postmenopausal osteoporosis by using an ovariectomized (OVX) mice model. The results from in vivo experiments showed that after daily oral administration of acteoside (20, 40, and 80 mg/kg body weight/day) for 12 weeks, bone mineral density and bone biomechanical properties of OVX mice were greatly enhanced, with significant improvement in bone microarchitecture. Furthermore, biochemical parameters of bone resorption markers as well as bone formation index, including tartrate-resistant acid phosphatase, cathepsin K, deoxypyridinoline, alkaline phosphatase, and bone gla-protein, were ameliorated by acteoside treatment, whereas the body, uterus, and vagina wet weights were seemingly not impacted by acteoside administration. Acteoside significantly affected osteoclastogenesis by attenuating nuclear factor kappa B (NF-κB) and stimulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal pathways through down-regulated levels of tumor-necrosis factor receptor-associated factor 6 (TRAF6), receptor activator of nuclear factor kappa B ligand (RANKL), RANK, NFKBIA, IκB kinase β, nuclear factor of activated T-cells c2 (NFAT2), and up-regulated expressions of PI3K, AKT, and c-Fos. Accordingly, the current research validated our hypothesis that acteoside possesses potent anti-osteoporotic properties and may be a promising agent for the prevention of osteoporosis in the future.

Study Type : Animal Study

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