Abstract Title:

Probiotic mixture containingandattenuates 5-fluorouracil-induced intestinal mucositis in mice.

Abstract Source:

Nutr Cancer. 2019 Oct 12:1-11. Epub 2019 Oct 12. PMID: 31608714

Abstract Author(s):

Marielle Quaresma, Samara Damasceno, Carlos Monteiro, Francisco Lima, Tiago Mendes, Marcos Lima, Priscilla Justino, André Barbosa, Marcellus Souza, Emmanuel Souza, Pedro Soares

Article Affiliation:

Marielle Quaresma


spp. andspp. was used to protect against gastrointestinal disorders. The present study evaluated the effects of probiotic mixture (PM) containingandon intestinal mucositis induced by 5-fluorouracil (5-FU). Swiss male mice (25-30 g) were treated with 5-FU (450 mg/kg, ip) and were orally administered (PM). Probiotic mixture 1 (PM-1) is a mixture of two probiotics (andand probiotic mixture 2 (PM-2) is a mixture of four probiotics (,,, and. PM-1 and PM-2 decreased histopathological scores in the duodenum and jejunum after mucositis. PM-2 attenuated 5-FU-induced weight loss. On the other hand, PM-1 did not exert a significant effect on weight loss. Both probiotics mixture increased the villus/crypt ratio in all intestinal segments, increased GSH levels in the duodenum and jejunum, and reduced the MDA, MPO, TNF-α, and IL-6 levels in the duodenum, jejunum, and ileum. PM-2 attenuated the delay in gastric emptying. PM-1 and PM-2 prevented epithelial injury in intestinal mucositis by 5-FU, demonstrating the potential use of these probiotics as therapeutic agents against intestinal mucositis.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.