Abstract Title:

Preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and nuclear factor-κB inflammatory signaling pathway in isoproterenol-induced myocardial infarcted rats.

Abstract Source:

Eur J Pharmacol. 2022 Jun 5 ;924:174909. Epub 2022 Mar 25. PMID: 35346644

Abstract Author(s):

Stanely Mainzen Prince Ponnian

Article Affiliation:

Stanely Mainzen Prince Ponnian


Myocardial infarction (MI) is a life-threatening condition. No studies were conducted earlier on the effects of (-) epicatechin (EC) on tachycardia, cardiac hypertrophy, and inflammation in MI. Hence, the preventive effects of EC on tachycardia, cardiac hypertrophy, and nuclear factor-κB inflammatory signaling pathway in experimental MI were appraised. This investigation included 4 groups of 24 male albino Wistar rats. Group:1. Normal control, Group: 2. EC (20 mg/kg body weight), Group: 3. Isoproterenol (100 mg/kg body weight), Group:4. EC (20 mg/kg body weight) + Isoproterenol (100 mg/kg body weight). MI was created in rats by isoproterenol (100 mg/kg body weight). The heart rate, heart weight, plasma myoglobin, serum cardiac troponin I, heart conjugated dienes, serum high-sensitivity C-reactive protein, and plasma total homocysteine were considerably (P < 0.05) raised in isoproterenol-induced myocardial infarcted rats. Further, reverse transcription-polymerase chain reaction study revealed a considerable (P < 0.05) increase in the expressions of heart pro-inflammatory cytokines such as nuclear factor- κB, tumor necrosis factor-α, interleukin-1β, interleukin-6, and a considerable (P < 0.05) decrease in anti-inflammatory cytokine gene, interleukin-10 in myocardial infarcted rats. Non-enzymatic antioxidants such as vitamin C, and vitamin E were considerably (P < 0.05) lessened in the heart. EC (20 mg/kg body weight) pre-treatment orally, daily, for 3 weeks prevented all changes in the above-mentioned functional, structural, biochemical, and molecular parameters investigated and improved cardiac function. The possible mechanisms are EC's anti-tachycardial, anti-cardiac hypertrophic, antioxidant, and anti-inflammatory effects.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.