Article Publish Status: FREE
Abstract Title:

In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation.

Abstract Source:

J Appl Microbiol. 2003 ;95(4):709-11. PMID: 12969283

Abstract Author(s):

C Pérez-Giraldo, G Cruz-Villalón, R Sánchez-Silos, R Martínez-Rubio, M T Blanco, A C Gómez-García

Article Affiliation:

C Pérez-Giraldo


AIMS: The aim of this study is to determine the in vitro activity of allicin against Staphylococcus epidermidis and to evaluate the influence of allicin on biofilm formation.

METHODS AND RESULTS: In vitro activity of allicin (diallyl thiosulphinate) against 38 strains of S. epidermidis was investigated. The activity of allicin was similar against S. epidermidis methicillin susceptible and methicillin resistant strains [minimum inhibitory concentration (MIC)90=8 mg l(-1)]. In general, subinhibitory concentrations (sub-MIC) of allicin diminished biofilm formation in the five strains analysed.

CONCLUSION: The results confirm the antibacterial effect of allicin. Sub-MICs of allicin also diminished the biofilm formations by S. epidermidis.

SIGNIFICANCE AND IMPACT OF THE STUDY: The present study shows that allicin is active in vitro against S. epidermidis and that sub-MICs of allicin may play a role in the prevention of adherence of this bacteria to medical devices.

Study Type : In Vitro Study

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